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Drugs 79 , 12411247 (2019)

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Recommended first-line choices in the guideline from the Canadian Network for Mood and Anxiety Treatments (CANMAT) and the International Society for Bipolar Disorders (ISBD), The most recent authoritative international guideline for the management of patients with bipolar disorder by the CANMAT and the ISBD (2018) [12] recommends the following first-line drugs for bipolar depression: quetiapine, lithium, lamotrigine and lurasidone

The standard of care is the same as with any GH-pathway intervention: full clinical intake, contraindication review, and lab monitoring

Denatured proteins are precipitated by cooling and removed via centrifugation, keeping of NAD + , NADH, NADP + , NADPH, GSSG and GSH stable in the supernatant